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Friday, January 28, 2011
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A Researchers from the Universities of Cambridge and Edinburgh (UK) have created transgenic chickens for the first time unable to transmit avian influenza. Sometimes, this disease to poultry and the virus spreads rapidly among animals. According to the authors of the research, transgenic chickens designed by them not only serve as protection for poultry in poultry farms, but could reduce the risk of new epidemics that could potentially spread to humans, as has happened on several occasions with the H5N1 strain in recent years.
Although the original strain of virus does not affect humans, is an agency in flux, and is the result of chance that one of these natural changes allow the transmission and human infection.
For this reason, the team led by Laurence Tiley, a specialist in molecular virology at the University of Cambridge, inserted into the genome of a group of chickens a strand of DNA that prevents disease from one animal to another. This genetic sequence transgenic birds makes manufacturing a small molecule with hairpin RNA that acts as a decoy for the virus. Briefly, it works by binding and inactivating key molecule for the cleavage and spread of virus (an enzyme called polymerase).
The virus is unable to pass from one individual to another regardless of whether it is a transgenic bird or a non-genetically modified. Although chickens infected with H5N1 are still dying with the same frequency as non-transgenic birds. For this reason, the team led by Laurence Tiley, a specialist in molecular virology at the University of Cambridge, inserted into the genome of a group of chickens a strand of DNA that prevents disease from one animal to another. This genetic sequence transgenic birds makes manufacturing a small molecule with hairpin RNA that acts as a decoy for the virus. Briefly, it works by binding and inactivating key molecule for the cleavage and spread of virus (an enzyme called polymerase).
Some experts, such as the director of U.S. Public Health believes it is possible that the transgenic chicken is on world markets in a few years. But few experts think you need to demonstrate the safety of eggs and meat from these animals.
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